Tokyo was suddenly assaulted by the Great Collapse! The moment they heard it, everyone in the city fell into a coma. When they awoke, Tokyo was enveloped in a red mist. Though some plotted to escape, not a single person has made it through the red mist alive, and Tokyo has become inaccessible. Tokyo is now a shadowy and inaccessible city from which there is no escape! Five months later, the very last person still in a coma, univeristy student Kamina Chihiro awakens, and curtains rise on the fierce Vermillion legend!

The man who was like a father to the solitary Chihiro transforms into a giant troll before his eyes. When Chihiro is struck by the creature's blade, his eyes glow a deep red and something begins to awaken inside him!

Only the chosen warriors known as Vessels of Heroic Blood are able to turn their own blood into weapons. First Chihiro, then his friend Kotetsu awaken as Vessels of Heroic Blood. But who keeps transforming innocent people into monsters?!

Chihiro and his friends are bewildered by Dux's unexpected words. Believing he's destined to destroy everything in his life, Chihiro ignores the warnings of his friends and uses his immense power against Tokyo!

Chihiro can't stop thinking about what Yuri said to him. Does it have something to do with the lost memories of his childhood? The past Kakihara describes to Chihiro is a heartbreaking tragedy.

As a mysterious series of murders occur in Tokyo, Inuki goes missing. Chihiro desperately searches for Inuki, until Yuri appears before him. Meanwhile, Inuki continues to plunge towards destruction.

Chihiro and his friends are shaken by Inuki's death, but have no time to grieve as the agents of Chaos continue their mission to exterminate the Heroic Lineage.

I want to resist fate. I want to save my friends from death. Hoping to achieve these goals, Chihiro decides to work with agent of Chaos Yuri. He asks Marie, Tsubaki, and the Guardian State to fight with him. Rather than destroying Tokyo, he believes the best option is for everyone to work together so the Heroic Lindeage survives. However, fate does not abide such naive thoughts, and instead leads Chihiro to the worst possible end...!

Chihiro is betrayed by Yuri and deserted by the Guardian State. No matter how much he fights them, his prophetic dreams of despair keep coming true. Despite this, he continues to desperately struggle to change fate. Chihiro's behavior inspires Kakihara to look into his past again. Did Chihiro really kill is own father?! What truth is hidden within that bloody tragedy?! Meanwhile, Chihiro dreams of Kakihara's death.

The AVAL Science Foundation has been attempting to cause a Second Great Collapse by installing artificial keystones throughout the city! At this rate, everyone in Tokyo will be transformed into monsters, and the city will become a hellscape! In order to stop their plot, Chihiro and his friends head to the Infinity Theater where Kark Kaburagi is performing a concert. As the reaper's deadly melody rings throughout the theater, total war breaks out between Chihiro's friends and the AVAL Science Foundation. Will they be able to stop the Second Great Collapse?!

Are the vessels of Heroic Blood destined to fight one another and die? Friend and foe alike are slain by the end of a bloody battle. However, the survivors must continue to fight for the fate of the world.

The gate to another world is finally opened, and Tokyo begins to collapse! As Chihiro and his allies head to the location of their final confrontation in order to end it all, a terrifying enemy blocks their path!