Koichi arrives in Italy on a mission from Jotaro to find Giorno; they meet haphazardly when Giorno steals Koichi's luggage, and the ensuing chase leads Giorno into a Stand battle with the gangster Leaky Eye Luca.

Faced with Bucciarati's Stand, Sticky Fingers, Giorno desperately uses Gold Experience to defend himself.

Giorno is interviewed by a strange man to enter the Passione gang and achieve his dream of becoming a "Gang-Star".

After apparently failing Polpo's test, Giorno is attacked by his stand, Black Sabbath, who tries to pierce his soul with a stand arrow.

News of Polpo's death reach the organization, along with word that he had a huge fortune hidden somewhere. Meanwhile, Giorno meets Buccellati's gang.

Bucciarati and Abbacchio are the only members of the gang left in the yacht. They have to find out where the enemy stand is hiding and how does it work.

After defeating Zucchero, the gang realizes that he has already told someone else where they were going and why.

Mista chases a Passione member named Sale to stop him from finding Polpo's treasure.

After being promoted to capo, Bucciarati and his gang are tasked to protect the boss' daughter.

Narancia discovers that he is slowly shrinking due to the wound Formaggio's stand, Little Feet, had inflicted on him.

Formaggio traps the now miniature Narancia beneath his foot and attempts to interrogate him, but Narancia resists. A flashback shows Narancia's early life on the streets and his rescue by Bucciarati.

In order to protect Trish from the Hitman Team, Bucciarati and crew's second mission from the boss was to go find a key in Pompei for some kind of vehicle that should aid them later on. Following orders, Giorno, Abbacchio, and Fugo head to Pompei to retrieve the key. When they get there, Fugo notices a suspicious shadow reflecting in a mirror that happened to be placed on one of the pillars there...

The person hiding in the mirror was Illuso from the Hitman Team. Fugo ends up being dragged into the mirror by Illuso's Stand, Man in the Mirror. Fugo then summons his own Stand, Purple Haze. Despite Giorno wanting to find Fugo, Abbacchio decides to go look for the key, since that was their mission. However, once Abbacchio finds the key, he also gets dragged into the mirror world...

"Take Trish to Venice." With their next order from the boss, Bucciarati and his crew head to Naples Station. "Use the key at the water fountain with the turtle on the 6th platform." They find the water fountain, but can't find the place to use the key. Meanwhile, Prosciutto and Pesci from the Hitman Team follow Bucciarati and the others to Naples Station. Bucciarati figures out the mystery behind the key and gets on the express train to Florence, and Prosciutto and Pesci follow.

The Grateful Dead slowly begins to age everybody on the train. With his teammates affected, Mista goes alone to confront the enemy, only to encounter Pesci and his Beach Boy.

Number Six from Sex Pistols manages to warn Bucciarati about the enemies and fights back, but The Grateful Dead's powers are taking a toll on him. Bucciarati steels his resolve and throws himself out with Prosciutto out of the train that's going 150kph. Barely hanging onto life, Prosciutto uses The Grateful Dead again. Pesci decides to take Prosciutto's resolve to heart and attacks Bucciarati.

After defeating Prosciutto and Pesci, Bucciarati and the others head to Venice in a car. Melone from the Hitman Team finds some of Bucciarati's blood at the scene where the train had stopped and then activates Baby Face. The powerful remote-control Stand created by assaulting a woman on the train then goes after Bucciarati.

Using Babyhead's Stand's ability to turn human parts into other things, Giorno uses his Gold Experience to make parts for the human body. He rebuilds his own body and fights back. Meanwhile, another member of the Hitman Team who's also after Trish, Ghiaccio, was trying to regroup with Melone and was driving to Giorno's location.

Ghiaccio's Stand, White Album is able to envelop him like a bodysuit and able to freeze everything around him to extremely low temperatures. Giorno and Mista somewhat make it to Venice, despite being partially frozen by Ghiaccio. But in order to try to get away from Ghiaccio, Giorno drives their car into the canal and they get stuck. Mista tries to sacrifice himself, but Giorno tells him that what's important right now isn't for him to sacrifice himself but for him to have resolve.

Mista and Giorno were able to defeat Ghiaccio. They then confirm the mission on the disc and head to the location they're supposed to take Trish. Bucciarati goes up the tower with Trish, but while they're in the elevator, Trish suddenly disappears. Bucciarati then realizes what the boss's true motives are.

Bucciarati finds out that the boss's true motive is to eliminate Trish because of her relationship with him, causing him to betray the boss and save Trish. Meanwhile, Giorno feels something bizarre is going on as they waited for Bucciarati's return. The Boss's Stand, King Crimson rises.

Because of their own wills and their sense of justice, Bucciarati and the others end up betraying the organization. Trish also wants to find out who her father truly is, so she tells the others that her mother met her father in Sardinia. They all decide to have a meal in Venice before they leave and Narancia is suddenly attacked by a Stand. The boss's own personal elite guard was now on the move.

The Stand that attacked Narancia was named Clash and belonged to Squalo, a member of the boss's elite guard. On top of that, Narancia suddenly can only say the exact opposite of what he's thinking, thanks to the ability of Talking Head, the Stand of Squalo's partner, Tiziano. Using Narancia, Squalo and Tiziano throw the team into chaos. The two elite guard members put Narancia in danger, but he boldly faces them so they can get out of Venice safely.

After defeating Squalo and Tiziano, Bucciarati and the others head off to Sardinia to find out about the boss's past. They head to Marco Polo International Airport in order to get a jet, but a strange man was following them. Mista manages to kill the strange Stand user before they're able to call upon their Stand. Even though they're a bit put off at how simple that was, they get onto the jet and fly off. But once they're on the jet, Giorno hears a weird noise...

The man who was killed by Mista at the airport, Carne, was first able to activate his stand, Notorious B.I.G, after he died. Notorious B.I.G reacts to movement and it attacks Giorno, resulting in him losing both arms. This makes him unable to use Gold Experience’s abilities, but he gives life to his brooch and recreates his left hand. Trish decides that she’s going to protect that left hand and goes after the brooch, but she’s detected. When all seemed lost, Trish’s Stand is activated.

The summer of 1965... A woman gave birth to a baby boy inside a women’s prison that sat in the middle of the Adriatic Sea. Bizarrely, she hadn’t been near any man in two years, but somehow got pregnant now. Time passed, and a young man arrived at Sardinia. His name was Doppio. Meanwhile, the leader of the Hitman Team, Risotto, as well as Trish, Bucciarati and the rest of his team all arrive at Sardinia. Doppio encounters Risotto at Costa Smeralda.

Risotto figures out that Doppio must be a Stand user that the boss trusts in deeply because he’s able to hear the noise from a certain Stand. Risotto then uses his Stand Metallica against him. Metallica is able to control magnetic force and attacks Doppio. Doppio uses the part of the boss’s power he received from him. While they’re fighting, Risotto realizes that Doppio’s personality and actions seem to be changing and he realizes exactly who Doppio is.

In the aftermath of the battle between Risotto and Doppio, Abbacchio uses Moody Blues to try and uncover the boss's identity. But the boss is adamant about keeping his identity a secret and executes his next gambit against the group.

After his death, Abbacchio was able to leave the others a copy of the boss’s face and fingerprints with Moody Blues' replay. The others try to find out who the boss is with the fingerprint and suddenly get contacted by someone. The mysterious man tells them that the boss’s name is Diavolo and tells them that the secret behind defeating him lies in the arrow. Bucciarati and the others head to Rome to meet him.

Bucciarati and the others end up facing off with two assassins sent by the boss, Cioccolata and Secco. Cioccolata uses his Stand Green Day against them. His Stand creates a mold that makes living creatures rot away and he unleashed it upon the fishing village that Bucciarati and his crew arrived at. Bucciarati and the others manage to evade the attack for the most part and try to keep heading towards the Colosseum, but then Secco also uses his Stand, Oasis.

As soon as Ciccolata went up in a helicopter, Green Day’s ability’s murderous range grew even more. He then flies to Rome and tries to spread his murderous mold. Bucciarati and the others go to stop Ciccolata, but Secco gets in their way. Giorno and Mista go after Ciccolata while Bucciarati faces off with Secco.

After a fierce battle, Giorno and Mista were able to strike down Cioccolata. However, Secco happens to receive one last voicemail from Cioccolata and finds out there’s a secret to defeating the boss at the Colosseum. Secco realizes that Cioccolata probably lost and heads to the Colosseum to find out what this secret is. Bucciarati attacks Secco in order to stop him from getting to the Colosseum, but Secco’s Oasis gives him trouble. An intense battle then takes place right in front of the Colosseum.

Bucciarati managed to win in his battle against Secco, but his body was reaching its limit. The boss had already arrived in Rome and used Doppio to get closer to Bucciarati. Bucciarati’s condition worsens and he mistakes Doppio as Trish and Doppio plays along. The man with the secret to defeating the boss was waiting for them inside the Colosseum. Time then skips and the boss’s true identity is revealed.

Jean Pierre Polnareff holds the key to defeating the boss. The one who appeared before him wasn’t Bucciarati or his squad, but the leader of Passione, Diavolo himself. Diavolo tries to eliminate Polnareff once and for all and summons King Crimson, but then Polnareff summons Silver Chariot and it is pierced with the arrow. That’s when something happens to everyone in or nearby the Colosseum. They find themselves losing strength and all fall asleep. After waking from their deep sleep, they all realize something has changed.

After being pierced with the arrow, Silver Chariot becomes Chariot Requiem and goes berserk. As a result, everyone’s minds are switched. Among all the confusion, Polnareff reveals himself to Giorno and the others. If someone with power uses the arrow, they would be able to obtain the power to rule over the minds of all living creatures. Polnareff lets them know that there is more to their Stand’s usual Stand ability if they have access to the arrow. Giorno and crew reunite with Bucciarati and they all go to try and steal the arrow back from Chariot Requiem.

Because of Chariot Requiem’s true power, something starts happening to Polnareff’s body. This just makes Bucciarati and the others try to get the arrow back even quicker. But then Giorno states that Diavolo’s mind is possessing one of their bodies. Who will get to the arrow first, Giorno and the rest of the crew or Diavolo?

Diavolo had been possessing Trish’s mind and is able to solve the mystery behind Chariot Requiem, making it possible for him to take the arrow. Giorno and the others attack in order to get the arrow back, but their attacks are futile against Eulogy. The moment that Diavolo tries to pierce his Stand with the arrow, Bucciarati completely destroys Chariot Requiem. Giorno and the others begin their final showdown with the almighty Diavolo.

Giorno takes the arrow that Bucciarati and the others had acquired and stabs Gold Experience with it during the final battle with Diavolo. Gold Experience evolves into Gold Experience Requiem and doesn’t even allow Diavolo to reach the truth of "dying" and he is forced to meet an end that never truly has an end.

Before Giorno had met Bucciarati and the others, a certain florist appeared before Bucciarati. The florist tells him that his daughter had jumped off the roof of an apartment holding a strange looking rock and he wanted to find out the truth behind that bizarre incident. Mista is put in charge of this mission and he goes to track down Scolippi, a sculptor who was the daughter’s boyfriend. Scolippi tells Mista that they are all slaves to destiny, and then a bizarre rock appears in front of them, which tells them Bucciarati's fate.