Black Jack visits an island and performs an operation on an Iriomote cat, a baby, and a politician in that order.

Pinoko saves Sharaku from Kong, a bully, and they become friends. Then, Sharaku becomes sick and Black Jack operates on him, but a runaway gurney causes an IV needle to break off in his vein. Black Jack fails to extract the needle, but by a miracle it comes out on its own.

One day when Pinoko and Sharaku are playing by the park they encounter a scruffy dog that promptly steals Pinoko’s purse - but as they begin their pursuit, a truck hits the four-legged thief. Upset that the poor hound might die, Pinoko immediately calls for Black Jack to save the canine, but can she persuade him to let her keep her? this episode was aired in Japan at July 17, 2006, due to canceled baseball game, but was not labeled as Karte 03. Source: http://en.wikipedia.org/wiki/Black_Jack_%28manga%29

While Pinoko and Sharaku are playing in the park next to the apartment building, a stray dog steals Pinoko's purse and runs away. As Pinoko and the others chase after it, the stray dog is hit by a car right in front of them and is seriously injured, but Black Jack performs surgery and the dog survives. Black Jack names the stray dog Largo, and Pinoko takes a liking to it, but Black Jack makes it clear that he has no intention of keeping it. Then, Sharaku reveals to Pinoko an unexpected truth that happened right after her purse was stolen...

Kong's sister, Chaco, is bedridden at home due to illness. Chaco hopes that Black Jack, who cured her friend's illness, will also cure her, but she ends up being hospitalized. Kong had been asked by Chaco to look for Black Jack, and when she is hospitalized, he begins to look for him seriously. In the end, Kong is unable to find him, but comes up with the idea of having Keaton from the drama club play Black Jack to cheer up Chaco. Keaton agrees to pretend to be Black Jack, on one condition...

When the director of Manaka Hospital dies, an election is held between two doctors who have been recommended for the position of new director. Dr. Shiitake has the same 20 years of service as the other two candidates, but because he is a low-key person who is treated like an assistant, no one recommended him. Meanwhile, a collapse occurs at a construction site in the city. Black Jack happens to be nearby, and Shiitake, who is on his way home, provides first aid to the injured at the scene. Black Jack is surprised to learn that Shiitake, who has advanced medical skills, is just a regular member of the medical staff at Manaka Hospital.

Hisao tries to skip school by faking an illness, but his mother finds out. Hisao doesn't want to go because he doesn't want to be scolded by his homeroom teacher, Mr. Muramasa, for not being able to do math. The next morning, on his way to school, he is hit by a motorcycle, thinking that if Hisao gets sick or injured, he won't have to go. Muramasa is shocked to hear that Hisao is in such a critical condition that both of his legs will need to be amputated. He learns of Black Jack, who may be able to heal his legs without amputation, and calls him to ask for his help...

Pinoko comes to the zoo with Black Jack. Her goal is to see the white lion Luna Luna, but she is not on display due to poor health. Pinoko tells the elderly zookeeper in charge that she can get Black Jack to heal her. The old zookeeper asks Black Jack to diagnose Luna Luna, but is refused, saying it is outside his area of expertise. A few days later, the old zookeeper finds Black Jack's home and asks Black Jack to diagnose him again, but is refused again. However, the old zookeeper does not give up and waits for Black Jack under the eaves in the pouring rain...

Black Jack takes Pinoko to a Noh sushi restaurant. The chef, Taku, is so skilled that Black Jack considers him to be the best in Japan. Taku asks his husband for time off so he can go back to his hometown and treat his mother to the best sushi in Japan. Taku returns home for the first time in ten years, but is hit by a truck in the middle of town. Both of Taku's arms have to be amputated, and the driver, Akira, is sent to prison. Afterwards, Taku writes a petition and Akira is not charged. Then, Taku and Akira meet...

An elderly woman lives in a room at Tesema Hospital, run by her son, and when the rooms are full of patients she has to stay overnight away from home. As usual, the elderly woman goes around to her acquaintances' houses looking for a place to stay, but they either pretend not to be home or refuse her permission, so she can't find a place to stay. At night, it starts to rain, making visibility poor, and the elderly woman is almost hit by a car. The car was being driven by Black Jack. The elderly woman asks Black Jack to take her to a villa deep in the mountains where she used to live long ago...

A CD-ROM arrives at Black Jack's house via international mail, offering a reward of over 10 million dollars if he can cure a sick relative. Black Jack is surprised to learn that the patient is 200 years old. At first, Black Jack decides not to go because he has other patients, but he decides to treat the 200-year-old patient. When Black Jack and Pinoko arrive at a remote airport, the sender, Miriam, has come to pick them up. The group boards a jeep and heads to the village where the patient is waiting. When they enter a house on the outskirts of the village, they find an old man in rags sitting in his bed...

After seeing the pearl that Largo has retrieved from the rocks facing the sea, Black Jack heads from the backyard through a cave in the rocks to the cove. Seeing the shining pearl in the cove, Black Jack explains to Pinoko that it belonged to a friend he parted ways with 10 years ago, and begins to talk about what happened back then. 10 years ago, Black Jack treated an injured killer whale that washed up in the cove. As a thank you for the treatment, the killer whale brought the pearl to Black Jack in its mouth. Since then, Black Jack has named the killer whale "Triton," which keeps coming back to the cove after getting injured, and they have grown closer...

Pinoko watches the TV show "Big Mask" and becomes fascinated by the villain Goras. Takao, who plays Goras, is kind to her on location, and she becomes a fan of him. After filming, a staff member notices that Takao's leg is swollen, and asks his acquaintance Sharaku, who promises to introduce him to Black Jack. Takao is admitted to the Black Jack residence, much to Pinoko's delight. Later, Black Jack visits Takao's home. Takao's younger brother, Yukio, overhears a conversation between his mother and Black Jack and mistakenly believes that his brother has been captured by Black Jack...

Ichinoseki Kazuo, a high school student, is a popular gymnast who is set to compete in the Inter-High School Championships. After school, Kazuo practices on the rings and feels pain in his left arm, but he endures it and continues practicing. His childhood friend, Furukawa Toshie, notices something strange about Kazuo's left arm and calls his mother, who then takes Kazuo to Tezuka Clinic for a checkup. He is diagnosed with the early symptoms of a vertebral column, but Kazuo continues practicing in preparation for the Inter-High School Championships. As a result, the condition of his left arm worsens. Black Jack examines him at Dr. Tezuka's request and determines that the only option is to amputate his arm.

Pinoko and Sharaku go to the pool. There, Pinoko is rescued from drowning by a young man named Musashi. The two become friends with Musashi. Musashi's job is as an animator, drawing animation. Worried that he cannot create realistic animation with a limited budget and number of frames, Musashi considers quitting his job, but is persuaded by Pinoko and the others to return to his passion for his work. Just then, while teaching Pinoko and the others how to swim in the pool, Musashi suddenly collapses. Pinoko contacts Black Jack for help, but...

While hospitalized, Michiru learns that she has only a short time left to live and declares that she will marry the first man who enters her hospital room. Her father calls Michiru's childhood friend Kuma to explain the situation. Kuma agrees to marry Michiru and heads to the hospital. As Michiru is in a stable condition and waiting for a male visitor, she hears a knock on the door. It is not Kuma who enters her hospital room first, but Black Jack, who has been asked by the hospital to perform surgery. Michiru declares that she will marry Black Jack, and wedding preparations begin...

Black Jack is performing a difficult operation on a thoracic aortic aneurysm at a hospital, while a representative from the World Medical Associations Federation watches him. Meanwhile, Pinoko, who is at home alone, discovers the thief Genkichi. After hearing Genkichi's unfortunate story, Pinoko promises to bring him the money when she has it. The next morning, Black Jack receives a call from the World Medical Associations Federation. They have learned that the talented Black Jack is an unlicensed doctor, and will be negotiating with the Japan Medical Association to have him issued a medical license. Meanwhile, Pinoko is visiting Genkichi's house with the pocket money she borrowed from Black Jack...

Asato Rei, who is in charge of the school's internal broadcasting system at a certain high school, has a beautiful, bright voice and is something of an idol at school. However, one day, her classmate Kumiko notices Rei coughing in pain. After school, Rei, a member of the choir club, practices in the gymnasium for the choir competition that is coming up in three months. In the evening, Rei tells Kumiko that he has something to discuss with her, and the two go to TOM, the cafe where Black Jack also has coffee. Rei bursts into tears when he hears that his voice has disappeared. Black Jack, who has been listening to her story, examines her and finds out that Rei has a vocal polyp...

Jun has a best friend named Tom who lives in New Zealand, but he has never met him. The two enjoy chatting on the computer. Jun tells Tom that he hit a home run in baseball, but in fact this is a lie. Jun has an illness that prevents him from exercising, and he can't have surgery until he becomes an adult. During the chat, Tom reveals that he plans to go to Japan next month, and Jun worries that his lie will be exposed. Then Black Jack appears, examines Jun, and explains that he can cure his illness, but...

Black Jack and Pinoko are traveling in Nagano when they see Tsuyuko with bulging eyes and a swollen throat on the bus. As Tsuyuko's mother comforts her in pain, Pinoko suddenly develops a stomachache. Black Jack decides to have Pinoko examined at Furuwa Hospital in Yamaya Village, where the mother and daughter are heading. Black Jack and his friends follow the mother and daughter to Furuwa Hospital, which is tucked away deep in the mountains. After prescribing medicine for Pinoko, Dr. Furuwa examines Tsuyuko. Furuwa tries to cure her with medicine, but Black Jack advises that surgery would be better. Tsuyuko has Graves' disease...

The owner and Black Jack are taken aback by the appearance of Tomobiki, a detective who appears at the cafe "Tom." The owner explains to Tomobiki that he used to be in the care of the police, but has now left bad habits behind. However, Tomobiki's reason for coming is to request that Black Jack, an unlicensed doctor, appear at the police station. After this, Tomobiki's gaze turns to the scar from surgery on the owner's right hand. The owner then thanks the two for restoring his fingers to their original state, and reminisces about 10 years ago when he was a magician called Tetsu...

Black Jack examines Kumiko, who is blind in one eye, and diagnoses her with albinism. Black Jack quickly arranges for a cornea to be transplanted, and the surgery is a success. Two months pass, and Kumiko, feeling much better, has a vision of a handsome man staring at her in the shopping district. From then on, she begins to have frequent visions of the same man. Black Jack consults her and contacts Dr. Tezuka, who arranged for the cornea, and asks him to look into the donor. Meanwhile, Kumiko actually meets the man from her vision, Kishida, in the shopping district...

Pinoko becomes friends with a boy named Cinque. When she gets home, the letter she starts to write is a love letter. Curious, Black Jack asks her who the man is, but she refuses to tell him. After this, Pinoko goes on a date with Cinque, but Black Jack is not impressed. Treated like a child, Pinoko decides to become an adult and starts to act grown up by wearing makeup and adult clothes. Then, on the night of their umpteenth date, a sick person is brought into Black Jack's house. It turns out to be Cinque...

A genetically-enhanced deer, Nadare, is attacking forest workers. In the past, the deer was befriended by a young doctor and treated as his own sibling however the deer injures a woman and it`s up to Black Jack to save her. Source: crunchyroll

Black Jack believes he may have cholera, so he quarantines himself, leaving Pinoko to take care of a patient for a few days. He soon finds out that his illness is connected to both Pinoko and the patient. Source: crunchyroll

Black Jack recalls a story to Pinoko about the teacher and father of Eiji, a boy, whom he helped win an abacus competition. Source: crunchyroll

Black Jack, Pinoko and several rich men find themselves trapped in an underground, disaster-proof bunker. To make matters worse, the oxygen in the bunker is slowly being sucked out! Can Black Jack save them in time? Source: crunchyroll

Black Jack and Pinoko investigate a mysterious plague in Australia. Through a series of events, Black Jack contracts a deadly plague and realizes it is actually a parasite. Source: crunchyroll

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After being summoned to a foreign land Black Jack faces a mysterious Illness that ravages man and beast, causing their bodies to waste away.

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Black Jack meets a girl who looks like Pinoko and suffers from a bad cold and lungs problem due to living next to a factory that pollutes the air.