The introductory sequence shows Poemy fighting shadowy figures of various other magical girls such as Usagi Tsukino from Sailor Moon, Tickle from Majokko Tickle, Utena from Revolutionary Girl Utena, Megu and Non from Majokko Megu-chan, Mahoro from Mahoromatic, Sakura Kinomoto from Cardcaptor Sakura, and the considered first magical girl in Japanese animation, Sally, from Sally, the Witch. At the start of a new school year the over-energetic Poemy Watanabe is introduced, along with her adoptive parents Nabeshin and Kumi-Kumi. Poemy rushes to the school to be the first there, at the same time she repeatedly proclaims her desire to become a successful voice actress. At the school, Poemy's best girl friend, Futaba Aasu, is presented as Poemy's biggest supporter and in fact perennially sexually attracted to her. Back from school, Poemy and Futaba realize the horror of finding Poemy's parents and their robot dog crucified by Alien #1, an extraterrestrial assassin with peculiar genitalia. Her home destroyed, Poemy moves in with Futaba and her six sisters. Later, a massive alien robot attacks the city, whereupon it turns out that Futaba and her sisters are actually a secret team of super-powered heroines dedicated to defending the Earth, also known as Sol III. Unfortunately, the Aasu sisters' magic is strictly defensive, so they are unable to defeat the rampaging robot. Meanwhile, Poemy obtains a talking, magic fish that when used as a magic wand transforms her into Puni Puni Poemy, a powerful magical girl. After the typical transformation, however, she promptly throws away her wand, forgoes the use of magic, and attacks the robot with her bare hands.

Continuing from the previous scene, the wastefully energetic Poemy uses her new powers to tear through the alien mecha, destroying it. Next, Poemy decides to use her new strength to continue pursuing her career as a voice actress, and right wrongs as she sees them throughout society. However, Poemy appears to do more bad than good, as she harshly punishes citizens for small incidents, and accidentally sends a nuclear missile off-course, completely destroying an entire country. Then, the Aasu sisters finally decide to confront Puni Puni Poemy, and realize she is actually the Poemy Watanabe they have been hosting in their own house. Afterwards, it is revealed that K, the school boy whom Poemy is attracted to, is actually an octopus-like alien, and he will be commanding the following invasion to Earth. Next morning, the invasion proceeds, with a massive Death Star en route to Earth, and with K capturing the Aasu sisters, and subjecting them to hentai-related bondage, as he learned from Japanese animation. In the end, the two alien henchmen are inexplicably revealed to be Poemy's foster parents, Nabeshin and Kumi-Kumi, who are thus not dead, and Poemy and Futaba combine their powers in order to make the world nice and end the extraterrestrial menace.